We encourage you to look inside the latest issue of NAUKA INNOWACJE BIZNES magazine. Find a minute to read an interview with Prof. Agnieszka Chacińska and learn more about our Institute.

Mehlich et al. identified the novel functions of protein kinase MLK4 in promoting chemoresistance to triple-negative breast cancer (TNBC), the most aggressive subtype of breast cancer. The group discovered that inhibiting MLK4 sensitizes TNBC cells to DNA damaging agents, such as doxorubicin, a commonly used drug in breast cancer treatment. The team also showed the […]

Ever wondered how information on oxidative stress is relied from mitochondria to the cytosol? https://9500d8a3-10d6-46dd-b789-a2cb14c8025e.usrfiles.com/html/2b2e4b_d767b483cae16e027c4ea8ac7906fbf4.html In the recent paper from the Wang group, Li et al describe a novel oxidation – driven mechanism concerning the power houses of the cell, mitochondria, and linking oxidation of the protein shaping mitochondria membranes (dMIC60) with removal of mitochondria […]

Zaktualizowano: 2 mar 2022 The surprising discovery of Maria Sladowska et al. was just published in PLOS Biology Proteins are the workhorses in the cell. However, the excess of their dysfunctional forms is dangerous. Thus, protein degradation mechanisms evolved to clear such proteins. One major protein clearance pathway involves a complex machine called the proteasome. The […]