Agnieszka Bartoszewicz, PhD

Core Facility Leader

ORCID ID: 0000-0002-1534-2690
MEDICINAL CHEMISTRY CORE FACILITY

  • about
  • MEMBERS OF THE GROUP
  • core facility leader
  • PUBLICATIONS
  • Patents

About

The Medicinal Chemistry Core Facility at the International Institute of Molecular Mechanisms and Machines (IMol PAS) provides advanced expertise and instrumentation in synthetic organic and medicinal chemistry to support IMol researchers and external collaborators in the design, synthesis, and optimization of biologically active molecules.

Led by Dr. Agnieszka Bartoszewicz, a medicinal chemist with extensive experience in both academia and the pharmaceutical industry, the facility bridges the gap between chemical synthesis and molecular biology, driving translational discoveries from chemical tools to potential therapeutic candidates.

Mission and Scope

The facility’s mission is to enable cutting-edge chemical research within IMol, offering support in the synthesis, purification, and analytical characterization of small molecules and chemical probes. By combining synthetic innovation with biological insight, the Medicinal Chemistry Core Facility strengthens IMol’s position as a hub for interdisciplinary research in molecular medicine, chemical biology, and drug discovery.

The facility collaborates closely with research groups across IMol and with external academic and industrial partners to develop new molecular probes, inhibitors, and drug-like compounds addressing key biological questions and disease mechanisms.

Members of the group

NameSurnameDegreeE-mail
AgnieszkaBartoszewiczPhDa.bartoszewicz@imol.institute

About Core Facility Leader

Dr. Bartoszewicz earned her Ph.D. in Organic Chemistry from Stockholm University and completed a prestigious postdoctoral fellowship at the California Institute of Technology in the group of Prof. Gregory C. Fu, where she developed groundbreaking asymmetric C–N coupling methods published in Science and JACS.

Before joining IMol, she served as Associate Director and Principal Scientist of Medicinal Chemistry at Molecure S.A., leading multidisciplinary teams (5–14 chemists) in four major drug discovery programs within the chitinase and chitinase like proteins inhibitors platform of projects (including the preclinical development of the clinical candidate OATD-01, currently in phase II clinical trials).

Funding

2016-2022
  • NCBR POIR.01.01.01-00-0552/16: Development of first-in-class YKL-40 inhibitors for oncology – 24.4 million PLN (Project Lead)
2013-2015
  • Bengt Lundqvist Memorial Foundation (Swedish Chemical Society) – Postdoctoral project on photoinduced copper-catalyzed asymmetric C–N cross-coupling reactions – 300000 SEK

Publications

2024
  • Mechanism of Catalytic Apparatus of Human Chitotriosidase-1 and Its Dual Inactivation Mode by the First-in-Class OATD‑01 Inhibitor. Niedziałek, D.; Wieczorek, G.; Drzewicka, K.; Antosiewicz, A.; Milewski, M.; Bartoszewicz, A.; Olczak, J.; Zasłona, Z. ACS Catalysis accepted (bioRxiv 2024.12.18.628861)

 

  • The Exploitation of the Glycosylation Pattern in Asthma: How We Alter Ancestral Pathways to Develop New Treatments. Muchowicz, A.; Bartoszewicz, A.; Zaslona, Z. Biomolecules 2024, 14, 513.

 

  • Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1. Czestkowski, W.; Krzemiński, Ł.; Piotrowicz, M. C.; Mazur, M.; Pluta, E.; Andryianau, G.; Koralewski, R.; Matyszewski, K.; Olejniczak, S.; Kowalski, M.; Lisiecka, K.; Kozieł, R.; Piwowar, K.; Papiernik, D.; Nowotny, M.; Napiórkowska-Gromadzka, A.; Nowak, E.; Niedziałek, D.; Wieczorek, G.; Siwińska, A.; Rejczak, T.; Jędrzejczak, K.; Mulewski, K.; Olczak, J.; Zasłona, Z.; Gołębiowski, A.; Drzewicka, K.; Bartoszewicz, A.* J. Med. Chem. 2024, 67, 395 (*corresponding author)
2022
  • Second Generation of Nucleotide Analogues Gołębiewska, J.; Bartoszewicz, A.; Kalek, M.; Stawiński, J. Phosphorus, Sulfur Silicon Relat. Elem. 2022, 197 (5–6), 511.
2020
  • A Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. Koralewski, R.; Dymek, B.; Mazur, M.; Sklepkiewicz, P.; Olejniczak, S.; Czestkowski, W.; Matyszewski, K.; Andryianau, G.; Niedziejko, P.; Kowalski, M.; Gruza, M.; Borek, B.; Jedrzejczak, K.; Bartoszewicz, A.; Pluta, E.; Rymaszewska, A.; Kania, M.; Rejczak, T.; Piasecka, S.; Mlacki, M.; Mazurkiewicz, M.; Piotrowicz, M.; Salamon, M.; Zagozdzon, A.; Napiorkowska-Gromadzka, A.; Bartlomiejczak, A.; Mozga, W.; Dobrzański, P.; Dzwonek, K.; Golab, J.; Nowotny, M.; Olczak, J.; Golebiowski, J. Med. Chem. 2020, 63, 15527.

 

  • Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. Andryianau, G.; Kowalski, M.; Piotrowicz, M. C.; Rajkiewicz, A. A.; Dymek, B.; Sklepkiewicz, P. L.; Pluta, E.; Stefaniak, F.; Czestkowski, W.; Olejniczak, S.; Mazur, M.; Niedziejko, P.; Koralewski, R.; Matyszewski, K.; Gruza, M.; Zagozdzon, A.; Salamon, M.; Rymaszewska, A.; Welzer, M.; Dzwonek, K.; Golab, J.; Olczak, J.; Bartoszewicz, A.*; Golebiowski, A. ACS Med. Chem. Lett. 2020, 11, 1228. (*corresponding author)
2019
  • Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases. Mazur, M.; Dymek, B.; Koralewski, R.; Sklepkiewicz, P.; Olejniczak, S.; Mazurkiewicz, M.; Piotrowicz, M.; Salamon, M.; Jędrzejczak, K.; Zagozdzon, A.; Czestkowski, W.; Matyszewski, K.; Borek, B.; Bartoszewicz, A.; Pluta, E.; Rymaszewska, A.; Mozga, W.; Stefaniak, F.; Dobrzański, P.; Dzwonek, K.; Golab, J.; Golebiowski, A.; Olczak, J.  J. Med. Chem. 2019, 62, 7126.

 

  • Enantioconvergent Alkylations of Amines by Alkyl Electrophiles: Copper-Catalyzed Nucleophilic Substitutions of Racemic α-Halolactams by Indoles. Bartoszewicz, A.; Matier, C. D.; Fu, G. C. J. Am. Chem. Soc. 2019, 141, 14864.
2018
  • Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Mazur, M.; Bartoszewicz, A.*; Dymek, B.; Salamon, M.; Andryianau, G.; Kowalski, M.; Olejniczak, S.; Matyszewski, K.; Pluta, E.; Borek, B.; Stefaniak, F.; Zagozdzon, A.; Mazurkiewicz, M.; Koralewski, R.; Czestkowski, W.; Piotrowicz, M.; Niedziejko, P.; Gruza, M. M.; Dzwonek, K.; Golebiowski, A.; Golab, J.; Olczak, J. Bioorg. Med. Chem. Lett. 2018, 28, 310. (*corresponding author)
2016
  • Asymmetric copper-catalyzed C–N cross-couplings induced by visible light. Kainz, Q. M.; Matier, C. D.; Bartoszewicz, A.; Zultanski, S. L.; Peters, J. C.; Fu, G. C. Science 2016, 351, 681.
2015
  • Mechanistic Studies on the Alkylation of Amines with Alcohols Catalyzed by a Bifunctional Iridium Complex Bartoszewicz, A.; González-Miera, G.; Marcos, R.; Norrby, P.-O.; Martín-Matute, B. ACS Catal. 2015, 5, 3704.
2013
  • Enantioselective synthesis of alcohols and amines via iridium-catalyzed hydrogenation, transfer hydrogenation, and related processes. Bartoszewicz, A.; Ahlsten, N.; Martín-Matute, B. Chem. Eur. J. 2013, 19, 7274.
2012
  • A Highly Active Bifunctional Iridium Complex with an Alcohol/Alkoxide-Functionalized N-Heterocyclic Carbene for Alkylation of Amines with Alcohols. Bartoszewicz, A.; Marcos, R.; Sahoo, S.; Inge, A. K.; Zou, X.; Martín-Matute, B. Chem. Eur. J. 2012, 14510.

 

  • Ruthenium Complexation in an Aluminium Metal–Organic Framework and its Application in Alcohol Oxidation Catalysis. Carson, F.; Agrawal, S.; Gustafsson, M.; Bartoszewicz, A.; Moraga, F. Zou, X.; Martín-Matute. B. Chem. Eur. J. 2012, 18, 15337.

 

  • Synthesis of -Hydroxy and -Amino Ketones from Allylic Alcohols Catalyzed by Ru-5-Ph5C5(CO)2Cl. Bartoszewicz, A.; Jezowska, M. M.; Laymand, K.; Möbus, J.; Martín-Matute, B. Eur. J. Inorg. Chem. 2012, 1517.

 

  • Allylic Alcohols as Synthetic Enolate Equivalents: Isomerisation and Tandem Reactions Catalysed by Transition Metal Complexes. Ahlsten, N.; Bartoszewicz A.; Martín-Matute, B. Dalton Trans. 2012, 41, 1660.
2011
  • Microporous Aluminoborates with 18- and 24-Octahedral-Atom Channels: Structural and Catalytic Properties. Yang, T.; Bartoszewicz, A.; Ju, J.; Sun, J.; Liu, Z.; Zou, X.; Wang, Y.; Li, G.; Liao, F.; Martín-Matute, B.; Lin, J. Angew. Chem. Int. Ed. 2011, 50, 12555.

 

  • Highly Enantioselective Co-Catalytic Direct Aldol Reactions by Combination of Hydrogen-Bond Donating and Acyclic Amino Acid Catalysts. Ma, G.; Bartoszewicz, A.; Ibrahem, I.; Córdova, A. Adv. Synth. Catal. 2011, 353, 3114.

 

  • A Facile Synthesis of -Fluoroketones Catalyzed by [Cp*IrCl2]2. Ahlsten, N.; Bartoszewicz, A.; Agrawal, S.; Martín-Matute, B. Synthesis, 2011, 2600.
2010
  • A Family of Highly Stable Lanthanide Metal−Organic Frameworks: Structural Evolution and Catalytic Activity. Gustafsson, M.; Bartoszewicz, A.; Martín-Matute, B.; Sun, J.; Grins, J.; Zhao, T.; Li, Z.; Zhu, G.; Zou, X. Chem. Mat. 2010, 22, 3316.
2009
  • Building molecular complexity via tandem Ru-catalyzed isomerization / C–H activation. Bartoszewicz, A.; Martín-Matute, B. Org. Lett. 2009, 11, 1749.

 

  • Inorganic ammonium salts as catalysts for direct aldol reactions in the presence of water. Dziedzic, P.; Bartoszewicz, A.; Córdova, A. Tetrahedron Lett. 2009, 50, 7242.

 

  • On the sulfurization of H-phosphonate diesters and phosphite triesters using elemental sulfur. Wallin, R.; Kalek, M.; Bartoszewicz, A.; Thelin, M.; Stawinski, J. Phosphorus Sulfur 2009, 184, 908.
2008
  • Iodine-promoted silylation of alcohols with silyl chlorides. Synthetic and mechanistic studies. Bartoszewicz, A.; Kalek, M.; Stawinski, J. Tetrahedron 2008, 64, 8843.

 

  • The case for the intermediacy of monomeric metaphosphates during oxidation of H-phosphonothioate, H-phosphonodithioate, and H-phosphonoselenoate monoesters. Mechanistic and synthetic studies. Bartoszewicz, A.; Kalek, M.; Stawinski, J. J. Org. Chem. 2008, 73, 5029.

 

  • Organocatalytic asymmetric nitrocyclopropanation of α,β-unsaturated aldehydes. Vesely, J.; Zhao, G. L.; Bartoszewicz, A.; Cordova, A. Tetrahedron Lett. 2008, 49, 4209.

 

  • A New Reagent System for Efficient Silylation of Alcohols – Silyl Chloride-N-Methylimidazole-Iodine. Bartoszewicz, A.; Kalek M.; Nilsson, J.; Hiresova, R.; Stawinski, J. Synlett 2008, 37.

 

  • Synthesis of Nucleoside Phosphorothio-, Phosphorodithio‑, and Phosphoroselenoate Diesters via Oxidative Esterification of the Corresponding H‑Phosphonate Analogues. Bartoszewicz, A.; Kalek, M.; Stawiński, J. Collect. Czech. Chem. Commun. 2008, 73 (10), 1654.

 

  • Synthesis of b-Hydroxy Ketones from Allylic Alcohols via Catalytic Formation of Ruthenium Enolates. Bartoszewicz, A.; Livendahl, M.; Martín-Matute, B. Chem. Eur. J. 2008, 14, 10547.
2007
  • D-glucosamine derivatives as ligands in highly enantioselective palladium-catalyzed allylic alkylations. Bartoszewicz, A.; Bauer, T. Pol. J. Chem. 2007, 81, 2115.

Patents

1.       WO2017037670 SUBSTITUTED AMINO TRIAZOLES USEFUL AS CHITINASE INHIBITORS (co-author)

2.       WO2021009209 SUBSTITUTED AMINO TRIAZOLES USEFUL AS CHITINASE INHIBITORS (project leader)

3.       US2023278996 YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS (project leader)

4.       US2023348516 YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS (project leader)

5.       P32133PC00/K YKL-40 AND CHITINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS (Patent application, project leader)